il 1 β antibody  (Boster Bio)

Journal: Acta Pharmaceutica Sinica. B

Article Title: Skin-penetrating peptides derived from computational simulation improve transdermal absorption and facilitate topical treatment of melanoma

doi: 10.1016/j.apsb.2025.12.026

Figure Lengend Snippet: Anti-melanoma efficacy in mice and safety evaluation. (A) Independent tumor volume-time curves of blank gel, 0.5% FUdR, 2.5% FUdR, 0.5% FUdR/589WP, 0.05% FUdR-589WP, and 0.5% FUdR-589WP gels ( n = 8). (B) Comparison between tumor volume-time curves of all groups ( n = 8). (C) Dissected melanoma issues of all groups ( n = 8). (D) Immunohistochemistry (IHC) staining with the IL-1 β antibody of skin sections. (E) Semi-quantitative average optical density (AOD) values of IHC sections ( n = 3). All gels were administered once a day to the skin above the melanoma area in C57BL/6 mice since tumor volume exceeded 100 mm 3 , with blank gel used as a negative control. The gel matrix consisted of 50% glycerin, 30% PEG 200, and 20% PEG 400 ( w / w ). Black arrows indicate the positive signals (scale bar = 50 μm). Data are presented as mean ± SD. ∗∗ P < 0.01, ∗∗∗ P < 0.001, and ∗∗∗∗ P < 0.0001 vs . indicated; ns, not significant.

Article Snippet: Hematoxylin-eosin (HE) staining solution and IL-1 β antibody were provided by Servicebio Technology, Wuhan, China.

Techniques: Comparison, Immunohistochemistry, Negative Control